RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
mir-190a-1
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
rattus norvegicus
Detection Methods
qRT-PCR; Dual-luciferase reporter assay; etc.
Target
Kcnq5
Pathway
NA
PubMed ID
Title
MicroRNA-190 regulates hypoxic pulmonary vasoconstriction by targeting a voltage-gated K channel in arterial smooth muscle cells
Year
2014
Function
"Hypoxia produced a significant increase of the miR-190 level in the pulmonary artery (PA). MiR-190 mimic enhanced enhanced the pulmonary vasoconstriction responses to phenylephrine (PE) and KCl. The voltage-gated K(+) channel subfamily member, Kcnq5 was a target for miR-190. MiR-190 appears to be a positive regulator of Ca(2+) influx, and plays an important role in hypoxic pulmonary vascular constriction."